Background: Diabetes mellitus and hyperlipidemia are the most common metabolic disorder affecting the people all over the world. Hyperglycemia is considered a primary cause of diabetic vascular complications and is associated with impaired electrolytes in some of the metabolic dysfunctions is not clear. Aim: The purpose of this study was conducted to investigate the relationship among diabetes mellitus, lipid profiles and electrolytes (Na+, K+ and Cl-). Methods: In the sera of 85 non insulin-dependent diabetes mellitus NIDDM, 45 with hyperlipidemia, 40 without hyperlipidemia, 50 samples of hyperlipidemia without NIDDM, and 50 non diabetic healthy control subjects. The mean age of the diabetic patients was similar to that of control. The mean duration of the disease was (10.2±5.9) years (2-23) years. From the results, it was discovered that there was a significant decrease in Na+ and Cl- in patients with NIDDM without high level of lipid profile (group I), but our results show that the concentration of K+ not changed significantly. The plasma levels of Na+ and Cl- ions were show significant change in patient with hyperlipidemia without NIDDM (group II), while plasma K+ not changed significantly in this group as compared with control. The mean value of Na+ and Cl- show high significant change in NIDDM patients with high level of lipids profile (group III),were plasma K+ not changed significantly as compared with control group. Conclusion: These finding may explain the role of impaired electrolytes status in NIDDM and hyperlipidemia subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.11088Asian Journal of Medical Sciences Vol.6(3) 2015 38-41

Elevation of gamma-glutamyltransferase (GGT) activity has been implicated in many pathologies, and clinical inhibitors of GGT are under development for use in the treatment of liver ,cancer, bone, and other diseases. In this study we try to find other new inhibitor of GGT, we used new polar amino acid (threonine) as inhibitor ,kinetic studies provide insight into the mechanism of inhibition. New uncompetitive inhibitors of physiological GGT reaction we found, development of new inhibitors is essential for exploiting GGT as a therapeutic target. L-threonine, in the presence study was detected as uncompetitive inhibitor, Km values were determined; we characterized the kinetic properties of GGT under a standard set of condition. Serum GGT was analyzed in healthy cases (normal 25:mean±SD) age 30±12 years,(16.71±0.87), the mean values of GGT levels were statistically significantly higher in liver syndrome(70.79±1.24),and this values decreased in the presence of inhibitor to (60.82±0.87).