Whitening creams are very popular among women, both teenagers, and adults. They are tempted to use whitening cream products so that their facial skin looks bright and smooth. The whitening cream they use is not necessarily the right whitening cream and guarantees safety. This study aimed to compare the knowledge and attitudes between adolescent girls and adult women toward the use of harmful whitening creams. This research was conducted in February 2022 in Mattampae Village, Ponre District, Bone Regency. This study uses a descriptive comparative method with a quantitative approach. The sample in this study amounted to 55 respondents consisting of 2 groups, namely 29 adolescent female respondents and 26 adult female respondents who were obtained using a purposive sampling technique. The questionnaire distributed contained knowledge and attitudes, then the data was processed using Mann Whitney with a 95% confidence level using the SPSS program. The results of this study indicate that the knowledge of adolescent girls is in a good category (79.7%) and adult women in the category are quite good (73.1%). The attitude of adolescent girls' attitudes are quite good (74.9%) and adult women are also quite good (72%). From the results of the study, it can be concluded that there is no significant difference in knowledge and attitudes between adolescent girls and adult women in Mattampae Village, Ponre District, Bone Regency towards the use of harmful whitening creams with a p-value > 0.05.