Introduction: Pseudoexfoliation syndrome is a systemic condition with eye manifestations. Ocular manifestations of PXS include iris depigmentation, phacodonesis or lens subluxation caused by zonular dehiscence. Loss of lens zonular support makes intraocular surgeries challenging with the potential for vitreous loss, lens subluxation or even lens dislocation. Current study was done to study the eyes with pseudoexfoliation, its association with cataract and its implications in cataract surgery. Material and Methods: A hospital based prospective study was conducted in 290 eyes (with PXF) of 170 patients attending ophthalmology OPD over a period of 3 years. Cataract surgery was performed for 156 eyes. Results: In the study, 54% (156 eyes) had cataract in association with PXF, out of which 62% (97eyes) were nuclear cataract. Complications associated with cataract surgery included vitreous loss, posterior capsular rent, zonular dialysis. Conclusion: PXS presents challenges that need careful preoperative planning and intraoperative care to ensure safe surgery and a successful post-operative outcome.