INTRODUCTION Breast cancer is a worldwide malignant disease. Over one million new cases of breast cancer are diagnosed every year. Cancer of Breast ,the most prevalent cancers in the developing country like India, is the highest registry of cancer among Indian women and important cause of morbidity and mortality ABO Blood Groups also has been associated with risk and survival of several malignancies, including pancreas cancer and stomach cancer, the mechanism is complex and yet unclear. AIMS AND OBJECTIVE To study histo-pathological type and grades of Breast Carcinoma. To find out ABO and Rh antigen expression in blood (ABO Blood Group) of respective Breast Carcinoma patients. To assess association between ABO Blood Groups and Breast Carcinoma. MATERIAL AND METHODS It is an Observational, Descriptive and Cross sectional study. The study will be carried out in the Department of Pathology with collaboration of Department of General Surgery, Blood Bank and Record Section of R.G. Kar Medical College and Hospital, Kolkata, over a period of 18 months. Over a period of 18 months. (After ethics committee clearance and acceptance from the West Bengal University of Health Sciences) sample size 114. RESULT AND ANALYSIS Among 114 cases, 18 were of Grade 1 while Grade II and Grade III comprised 46 and 50 cases respectively.18 Grade I cases, 72.2% (n=13) were Invasive Breast Carcinoma and 27.8% (n=5) were Lobular Carcinoma cases. Among 46 Grade II cases, 82.6% (n=38) were Invasive Breast Carcinoma, 10.9% (n=5) were Lobular Carcinoma, 4.3% (n=2) were Medullary Carcinoma and 2.2% (n=1) were Metaplastic Carcinoma cases and in 50 Grade III cases, 90% (n=45) were Invasive Breast Carcinoma, 8% (n=4) were Lobular Carcinoma and 2% (n=1) were Pleomorphic Carcinoma cases.