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A novel series of 2‐amino‐4‐aryl‐7,7‐dimethyl‐5‐oxo‐1‐(phenylamino)‐1,4,5,6,7,8‐hexahydroquinoline‐3‐carbonitrile derivatives has been designed using aryl aldehydes, 5,5‐dimethyl‐3‐(2‐phenylhydrazinyl)cyclohex‐2‐enone (phenylhydrazone of dimedone) and malononitrile with piperidine at room temperature. The structures of the synthesized compounds have been well elucidated by various spectroscopic techniques and X‐ray crystal diffraction studies. Selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.

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A convenient synthesis of 2′-amino-7′,7′-dimethyl-2,5′-dioxo-1′-(phenylamino)-5′,6′,7′,8′-tetrahydro-1′H-spiro[indoline-3,4′-quinoline]-3′-carbonitrile derivatives has been designed using different substituted isatins, various 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enones (arylhydrazones of dimedone) and malononitrile in ethanol with piperidine as catalyst at room temperature. The structures of the synthesized compounds have been elucidated by various spectroscopic techniques. The selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.