Organ identity specification factor WGE localizes to the histone locus body and regulates histone expression to ensure genomic stability in Drosophila S WGE contributes to genome stability Author ManuscriptThis article is protected by copyright. All rights reserved Understanding the mechanisms involved in regeneration-related events (including trans-determination of organ identity) observed in some model organisms is potentially Author ManuscriptThis article is protected by copyright. All rights reserved advantageous for regenerative medicine. Drosophila imaginal discs, the primordia of adult organs, are a valuable model for investigating how organ identity is specified and maintained during development, as the organ identity conferred to the imaginal disc is experimentally manipulatable (Hadorn 1968).We previously identified a chromatin-related protein, Winged-Eye (WGE), as a factor that induces eye-to-wing transformation upon its overexpression in the Drosophila eye imaginal disc (Katsuyama et al. 2005). Besides the unique phenotype caused by the forced expression of wge, its endogenous function is thought to be required for normal development of imaginal discs. For example, wge-deficient mutants exhibit a growth delay and are arrested at the larval stage. Furthermore, the wge mutation affects homeotic transformations caused by the mutation of Hox gene regulators that have important roles in the regulation of chromatin structure. These observations suggest that WGE has a crucial role in normal growth and organ development, probably through chromatin-related events. The precise role of endogenous WGE, however, remains unclear.Findings from recent studies suggest a dynamic interplay between gene expression, chromatin organization, and nuclear architecture. Nuclear architecture, including specific nuclear bodies/compartments, is involved in the regulation of nuclear processes such as DNA replication, gene transcription, RNA processing, and RNA

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This paper describes a man machine interface based on gazing input without user's body restrictions. Gazing points forward to the side directions were estimated by the relative distance of an iris and the outer corner of left and right eyes. Whether or not the user gazes the camera was recognized by the intersection of the two perpendicular bisectors derived by the position of a cornea and the eyelid edges. The suggested recognition system was applied to the operations of the page turner machine. It could judge the user's states of both reading a book and operating the machine by the special feature points on an eye.