No abstract

It is demonstrated that reaction of cyclic ketones tethering acyloxyalkyl side chains with SmI2 promotes novel intramolecular addition of samarium ketyl radicals to ester carbonyl resulting in formation of 2-hydroxy cyclic hemiacetals. In some cases, the yield can be improved by addition of tBuOH. -(HASEGAWA*, E.; OKAMOTO, K.; TANIKAWA, N.; NAKAMURA, M.; IWAYA, K.; HOSHI, T.; SUZUKI, T.; Tetrahedron Lett. 47 (2006) 44, 7715-7718; Dep. Chem., Fac. Sci., Niigata Univ., Ikarashi, Niigata 950-21, Japan; Eng.) -Mais 06-103