Drug-induced acute hemolytic anemia led to the discovery of G6PD deficiency. However, most clinical data are from isolated case reports. In 2 clinical trials of antimalarial preparations containing dapsone (4,4-diaminodiphenylsulfone; 2.5 mg/kg once daily for 3 days), 95 G6PD-deficient hemizygous boys, 24 G6PD-deficient homozygous girls, and 200 girls heterozygous for G6PD deficiency received this agent. In the first 2 groups, there was a maximum decrease in hemoglobin averaging ؊2.64 g/dL (range ؊6.70 to ؉0.30 g/dL), which was significantly greater than for the comparator group receiving artemether-lumefantrine (adjusted difference ؊1.46 g/dL; 95% confidence interval ؊1.76, ؊1.15).

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Background Neurodevelopmental outcomes are of paramount importance for every clinician as the survival rates of term and preterm babies have continued to improve. In NICU every intervention should be aimed at either promoting the neurodevelopment or prevent any further insult to a premature brain. We aim to provide a framework for developing a Neuroprotective strategy for the Neonatal Intensive Care Unit (NICU) by describing five main domains below. Objectives We achieve this in our NICU by a multi-disciplinary team consisting of neonatologists, respiratory therapists, occupational therapists, physiotherapists, social workers, pharmacists, and a dietician. This approach needs to be individualised for each unit based on the resources and services available. Methods Results Conclusions Neuro assessment: clinical neuro assessment remains the most important tool, with strong predictive value for long-term outcomes. It is important to develop other tools of assessment like comfort and pain scoring. We use comfort Neo-scale as standard care. Neuroimaging is another important factor in the assessment. We have an agreed guideline to decide the frequency and the timing of the neuroimaging like cranial ultrasound and MRI.Neuroprotection: Antenatal magnesium sulfate and antenatal steroids have become an established practice in most units 1,2 . Interventions like total body cooling have significantly improved the outcomes for babies with Hypoxic-ischemic injury. Optimal nutrition is another important element for the developing brain. We developed neonatal nutritional guidelines in collaboration with the clinical pharmacist and a dietician.