No abstract

Several alcohols were smoothly and practically tosylated by two Methods A and B. Method A uses the TsCl/ Me 2 N(CH 2 ) n NMe 2 (n = 3 or 6) reagent and Method B uses TsCl/ Et 3 N/catalytic Me 2 N(CH 2 ) n NMe 2 (n = 3 or 6) reagent. Compared with the traditional Py-solvent method, Method A has the advantages of its much higher reaction rate, operational simplicity, and circumvention of the undesirable side reaction from ROTs to RCl. Method B has the advantage of economy in the use of the amine. Related methanesulfonylations in toluene solvent also proceeded successfully.

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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.