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Objective:The main objective of our present study, is to potentiate the antibacterial activity of biphenyl chalcones and oxazolidinones, thus in order to achieve the potent antibacterial agents, we coupled both derivatives by using green chemistry approach for Buchwald's protocol under ultrasound irradiation. Methodology: Ultrasonication technique was used to couple a series of 24 novel bromo-biphenyl-chalcone derivatives and 5-chloromethyl-oxazolidinone in the presence of copper iodide (CuI) (10 mol %) for the amidation of chalcones and (±)-trans-1,2-diaminocyclohexane was used to solubilize CuI and potassium carbonate (K 2 CO 3 ) as base, which provided the products in good yields after short reaction times under mild conditions. Results and Discussion: Herewith we report the synthesis of 24 novel oxazolidinone-biphenyl chalcone hybrid derivatives (7a-7x). All the synthesized compounds were characterized by spectral data and evaluated for in vitro antibacterial and antifungal activities. Antibacterial and antifungal activities were tested using the serial dilution method. From the screening studies it was observed that compounds 7c to 7g have shown significant antibacterial activities against the both the strains of gram-positive and gram-negative bacteria at 3.125 µg/ml when compared to the standard drugs ciprofloxacin and linezolid and were as other compounds showed moderate to weak activities. In case of antifungal studies the compounds 7e-7g showed moderate activities at 12.5 µg/ml compared to standard fluconazole and whereas other compounds showed weak activities. Conclusion: We have developed an experimentally simple, efficient, short time and high yielding CuI-mediated N-arylation of oxazolidinones under ultrasound irradiation with a simple set up at room temperature. This approach would be a worthwhile in the development of green chemistry protocols. Compounds 7c to 7g have shown significant antibacterial activities against the both the strains of gram-positive and gram-negative bacteria.

Background:: A series of novel aryl (4-aryl-1H-pyrrol-3-yl) (thiophen-2-yl) methanone derivatives was synthe-sized from sequential addition reaction with chalcones and toluenesulfonylmethyl isocyanide (TosMIC). Methods: The de-rivatives were screened against anti-inflammatory, anti-ulcer activities with an inhibition of 80.65% for PY-5 compound at 200mg/kg and inhibition of 77.5% for PY-1 compound at 200mg/kg. Active anti-inflammatory agents were subjected to in-vitro Cyclooxygenase (COX) inhibition assay. The interactions between the synthesized compounds and active site residues of proteins COX-1 (3N8Y), COX-2 (1PXX), H+/K+ ATPase (2XZB) were investigated by using molecular docking studies using autodock 4.2. Results and Conclusion:: In silico drug likeliness and toxicity prediction studies were carried by OSIRIS property explorer and admetSAR prediction tool which predicts that two compounds of PY-5 and PY-1 shows a new class of potential anti-inflammatory and anti-ulcer agents and serves as new anti-inflammatory and anti-ulcer drugs after further investigation.

<em>Spondias pinnata</em> (L.f.) Kurz., belongs to the Anacardiaceae family, generally referred to as Indian Hog plum, a deciduous, glabrous tree with a healthy fruit to eat. Hog plum is a mild deciduous tree plant of high nutritional value, stubby calories and abundant in vegetable proteins, zinc, chitin, starch, vitamins and minerals. Traditional use of various parts of <em>S. pinnata</em> includes diarrhea, dysentery, stomach troubles, hyperacidity, wounds, sprain, rheumatism, gonorrhoea, tuberculosis, aphrodisiac, arrow poison antidote, dyspepsia, dysentery, ring worms, abscess painful joints, refrigerant, tonic, antiseptic, astringent, mental disorders, tuberculosis, vomiting and many more. A number of pharmacological activities were reported from several extracts of <em>S. pinnata</em> and its parts that include hypoglycemic, anti-cancer, ulcer-protective, antidiarrhoeal, anti-microbial, hepatoprotective, thrombolytic, anti-inflammatory, antiarthritic, analgesic, antipyretic, antihypertensive, anthelmintic, diuretic and laxative, anti-tuberculosis, cytotoxic, antioxidant, anti-hyperlipidemic, ischemia reperfusion injury and preconditioning of heart, anxiolytic, reduce side effects of chemotherapy, ameliorating, platelet aggregation inhibitory activity and acute and sub-chronic toxicity. A few phytochemicals were detailed on this plant. The chemical components of <em>S. pinnata</em> include different amino acids, carbohydrates, terpenoids, flavonoids, polysaccharides, steroids and so on. Various solvent extract and their gas chromatography-mass spectrometry analysis have confirmed the structures of a number of important phytoconstituents. Hence this review can be a good reference for researchers who would undertake further investigation about <em>S. pinnata</em>.