Two new bis(bidentate) azine ligands were prepared by linking (1 Z ,1 Z)-1,1 -{butane-1,4-diylbis[oxybenzene-4,1-diyl(1 Z) eth-1-yl-1-ylidene]}dihydrazine to salicylaldehyde and pyridine-2-carbaldehyde, 1,4-bis{4-and 1,4-bis{4-{(1 E) -1-((2E) -(pyridine-2-ylmethylidene)hydrazonylidene)ethyl}phenoxy}butane (L 2 ), respectively. Two kinds of copper(II) and nickel(II) complexes with different ligands were prepared. Reaction of H 2 L 1 with Cu(II) and Ni(II) acetate with 1:1 molar ratio gave double stranded binuclear bis(azine) complexes with stoichiometry [M(L 1 )] 2 containing {M II N 2 O 2 } centers. On the other hand, 1:1 molar ratio reaction of Cu(II) and Ni(II) chloride with L 2 yielded mononuclear metal complexes with general stoichiometry [M(L 2 )Cl 2 ] containing {M II N 2 N 2 } centers. The structures of both bis(azine) ligands and complexes were identified by elemental analysis, infrared spectra, UV-Vis electronic absorption spectra, magnetic susceptibility measurements, and TGA. DNA binding and DNA cleavage activities of the mononuclear complexes of L 2 , [M(L 2 )Cl 2 ] were examined by using UV-Vis titration and agarose gel electrophoresis, respectively. The results indicate that mononuclear complexes, especially [Cu(L 2) Cl 2 ], bind significantly calf thymus DNA and cleaves pBR322 DNA. Furthermore, the complexing properties of the bis-azine ligands toward selected transition metal cations and dichromate anions were also reported. It was found that bis(azine) ligands have high extraction ability towards dichromate anions.
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