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Background: Benign prostatic hyperplasia (BPH), the most common benign tumour in men. The present study was planned to assess quantitatively the symptom improvement with Terazosin and with Prazosin in patients with symptomatic BPH. Subjects and Methods: The present study was conducted on 30 patients. The patients were studied under two subgroups, allotted at random, each had 15 patients. The sub group A patients received prazosin GITS tablet and sub group B patients received Terazosin. The urinary symptom scores were measured by using AUA symptom index, comprising seven equally weighted questions addressing the severity of urinary symptoms. Results: The pre drug therapy symptom score in group A & B were comparable and there was no significant difference between the two subgroup of patients (P > .05). On comparison of improvement in AUA score between Group A and Group B, no significant difference was found (P > .05). There was also no significant difference in improvement of obstructive and irritative subscores between the two sub groups. Group B patients had significant reduction of the post void residual urine following treatment. Conclusion: Prazosin GITS is an effective formulation of Prazosin, which ensures single daily use of this agent. Prazosin GITS and Terazosin are equally effective in improving the bothersome symptoms of BPH in symptomatic patients.

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Background: Hypertensive disorders of pregnancy, particularly pre-eclampsia, are responsible for 10% to 15% of maternal deaths. The present study was conducted to compare LDH in preeclampsia versus normotensive pregnant women. Materials & Methods:The present study was conducted on 120 pre-eclampsia pregnant women age ranged 18-36 years of third trimester. Equal number of healthy women (group I) was taken as control. Patients were divided into mild preeclampsia (60) (group II-SBP >140 to <160mm Hg, DBP >90 to < 110 mm Hg) and severe preeclampsia patients (60) (group III-SBP > 160mm Hg, DBP > 110mm Hg). In all patients LDH level, BMI and proteinuria was determined. Results: Serum LDH level was significantly higher in preeclamptics compared to those of control. LDH was significantly higher in severe preeclamptics than those of mild preeclamptics. Conclusion: Authors found that there was significantly higher level of LDH in eclampsia and preeclampsia women as compared to normotensive women.

Mrs. S., a 23-year-old, married for 2 years presented to us with continuous leakage of urine for the last three months. The problem arose when she delivered a dead full term foetus at home by a dai in March 2016. She remained in labour for 2 days before delivery. After three days of delivery, she presented with continuous leaking of urine. She had to wear sterile pads most of the time for protection. Her medical history was unremarkable. This patient had complete total longitudinal disruption of all the muscular elements of the urethral sphincter. The diagnosis of longitudinal disruption of urethral sphincter was made followed by primary reconstruction with an approximation technique M. M. Koraintin et al. (1) The muscular elements were approximated taking care not to strangulate the tissues by overtightening the knots. A simple suture technique was used rather than mattress suture as in the case of anal sphincter repair. DIFFERENTIAL DIAGNOSIS Vesicovaginal Fistula This is an abnormal fistulous tract extending between the bladder and vagina that allows continuous involuntary discharge of urine into vagina (Lee RA et al 1988 (2)). Ureterovaginal Fistula This is a communication between the distal ureter and the vagina. The urine from the ureter bypasses the bladder and flows into vagina (Gerber GS et al 1993 (3)). Urge Incontinence This occurs when one has a strong sudden need to urinate. The bladder then squeezes or undergoes spasm and they leak urine. Stress Incontinence This is the involuntary loss of urine on coughing, sneezing, running or heavy weight lifting. Overflow Incontinence This is the involuntary release of urine. Due to weak bladder muscles or due to blockage-when the bladder becomes overly full, even though the person feels no urge to urinate.