Objectives:The main purpose of this work is to design a simple, sensitive, accurate and precise potentiometric membrane ion selective electrodes for selective determination of loperamide hydrochloride in bulk powder and in pharmaceutical preparation. Methods: Electrochemical behavior of loperamide hydrochloride were investigated using PVC membrane and modified carbon nanotubes paste sensors. The linearity of this developed method was established in the concentration range of 10 -5 -10 -2 M and 10 -6 -10 -2 M shows a Nernstian slope of 57.38 mV and 58.74 mV for PVC and Carbon paste sensor, respectively. Results: Validation parameters such as specificity, linearity, accuracy, precision, stability, limit of detection were found to be within the acceptance limit as studied according to IUPAC recommendation data. Conclusion: Both sensors ware successfully applied for potentiometric determination of loperamide hydrochloride in its pure form and pharmaceutical formulations.