a premalignant condition. 12 Oral leukoplakia, OLP, and OSCC are the most common oral diseases with specific clinical and histological features and in most cases are associated with chronic inflammation in adjacent connective tissue. 13 Decreased or increased expression of some molecular-protein markers in suspected malignant lesions has been somewhat effective in the early detection of oral cancer. Among many protein factors, two are clinically important including CD44 and E-cadherin. 14 CD44 is a membrane glycoprotein with various isoforms of V10 to V10 that results from different mRNA expression.