We report that the PPAR gamma C161-->T substitution is associated with a reduced CAD risk, particularly among CT heterozygous patients, but not with obesity in Australian Caucasian patients. It implicates that the PPAR gamma may have a significant role in atherogenesis, independent of obesity and of lipid abnormalities, possibly via a direct local vascular wall effect.
The p22 phox C242T polymorphism is not associated with the occurrence or severity of CAD or with a history of MI in Australian Caucasian patients aged = 65 years. However, the polymorphism could be associated with an increased CAD risk in young patients, which requires confirmation in large populations.
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