The authors of the article consider the problems of professional and personal competence development adequate to the digital economy challenges. They emphasized that it is necessary to shift the emphasis from obtaining only the knowledge component to a personality-oriented, developing cognitive activity in the traditional education system. The task of the modern education system should be to teach the listener to learn. As you know, the digital economy is based on the idea of transaction cost reduction because people are removed from value chains. Routine operations will be automated, and a number of professional activities will disappear. This will affect the labor market and its structure; in order to maintain his competitiveness, a person will have to look for a new application and complete his profile of professional competence quickly. In the age of innovation and rapid development of IT technologies, human capital will become the main economic resource of companies. It is the rational use of each person potential, the creation of conditions for his harmonious development that will determine a company competitive position in the market. The business community and the education system should become business partners that mutually influence each other in the context of digital transformation.

The article deals with the energy industry of the Donetsk People’s Republic. The specificity of such a commodity as electricity is highlighted. Based on this features of the electricity market are developed. The state of the electricity market, participants and decisions on improving the functioning of the power industry of the DNR are considered.

Aim. To study the dependence of the effectiveness of antihypertensive therapy on the polymorphic variants of candidate genes of the RAAS (ACE, AGT, AGTR1) in patients with hypertension (АH) of the population of Mountain Shoria. Materials and methods. In the conditions of the expeditions from 2013 to 2017, the population of Mountain Shoria was surveyed. Included 1409 people 18 years and older. Blood pressure monitoring was carried out as a result of office measurement, according to the standard recommendations of National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). As a result of the survey, patients with AH were identified for further observation (597 people) who need medical antihypertensive treatment. Repeat screening was conducted in a year. The criterion for inclusion in prospective observation of patients with hypertension was: regular intake of prescribed medication. 253 respondents were surveyed: indigenous (156 people) and non-indigenous (97 people) nationality. All patients underwent a standard examination, including the collection of complaints and anamnesis, an assessment of objective status, laboratory and instrumental studies. Polymorphisms of genes ACE (I/D, rs 4340), AGT (c.803T C, rs699), AGTR1 (A1166C, rs5186) were tested using polymerase chain reaction. Results. Dynamic observation of patients with hypertension found that in the cohort of Shors the target level of blood pressure reached the owners of heterozygous I/D and minor D/D genotypes of the ACE gene, carriers of T/C and C/C genotypes of the AGT gene and the homozygous genotype A/A of the AGTR1 gene. In the non-indigenous nationality cohort, only carriers of the D/D genotype of the ACE gene. Conclusion. National differences were identified with respect to the sensitivity of the pharmacological response to treatment, which once again proves the important role of taking into account the ethnic factor in the choice of drug.

Proceedings of the conference on current problems of our time: the relationship of man and society (CPT 2020)

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