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Despite the ambiguities revolving around the diagnosis of pediatric bipolar disorder (BP), there is well-established evidence from prospective studies of the high-risk offspring of bipolar parents that BP occurs at least in adolescent. [1][2][3][4][5] Current data show the prevalence of bipolar spectrum disorders, including bipolar I disorder, bipolar II disorder, cyclothymic disorder, bipolar disorder not otherwise specified, and other specified bipolar and related disorders in youth aged 7-21 years is 2.06% and the prevalence of BP-I in youth is 0.49%. 6 Studies have