Novel engineering materials and structures are increasingly designed for use in severe environments involving extreme transient variations in temperature and loading rates, chemically reactive flows, and other conditions. The Texas A&M University Hypervelocity Impact Laboratory (HVIL) enables unique ultrahigh-rate materials characterization, testing, and modeling capabilities by tightly integrating expertise in high-rate materials behavior, computational and polymer chemistry, and multi-physics multiscale numerical algorithm development, validation, and implementation. The HVIL provides a high-throughput test bed for development and tailoring of novel materials and structures to mitigate hypervelocity impacts (HVIs). A conventional, 12.7 mm, smooth bore, two-stage light gas gun (2SLGG) is being used as the aeroballistic range launcher to accelerate single and simultaneously launched projectiles to velocities in the range 1.5–7.0 km/s. The aeroballistic range is combined with conventional and innovative experimental, diagnostic, and modeling capabilities to create a unique HVI and hypersonic test bed. Ultrahigh-speed imaging (10M fps), ultrahigh-speed schlieren imaging, multi-angle imaging, digital particle tracking, flash x-ray radiography, nondestructive/destructive inspection, optical and scanning electron microscopy, and other techniques are being used to characterize HVIs and study interactions between hypersonic projectiles and suspended aerosolized particles. Additionally, an overview of 65 2SLGG facilities operational worldwide since 1990 is provided, which is the most comprehensive survey published to date. The HVIL aims to ( i) couple recent theoretical developments in shock physics with advances in numerical methods to perform HVI risk assessments of materials and structures, ( ii) characterize environmental effects (water, ice, dust, etc.) on hypersonic vehicles, and ( iii) address key high-rate materials and hypersonics research problems.