Introduction In the future, clinical dental students, as health service providers, will play a key role in the oral care of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Clinical dental students need to increase their knowledge of HIV because it is vital for the diagnosis and management of HIV/AIDS patients that they have a positive attitude regarding oral care behavior toward HIV/AIDS patients. This study aims to explain the relationship between the knowledge, attitudes, and behavior of clinical dental students in the oral care of HIV/AIDS patients at Airlangga University Dental Hospital. Materials and Methods This study used a cross-sectional approach with a sample of 132 respondents. The sample was taken by purposive sampling technique. The independent variable in this study was the attitudes and behavior of clinical dental students toward the care of HIV/AIDS patients. The dependent variable in this study was the knowledge and attitudes of clinical dental students toward the oral care of HIV/AIDS patients. The research data obtained were analyzed using Spearman's rho at ≤0.05. Result There was significant correlation between knowledge and attitudes (p = 0.001, r = 0.596); knowledge and behavior (p = 0.001, r = 0.637); attitudes and behavior (p = 0.001, r = 0.699) of dentistry students in the care of HIV/AIDS patients oral cavity. Conclusion Clinical dental students' knowledge of HIV/AIDS will influence their attitudes toward HIV/AIDS patients and their behavior in the oral care of HIV/AIDS. It is hoped that future research can be conducted by adding other independent variables to determine a wider range of factors that affect oral care in HIV/AIDS patients.