With no predicted indication of adverse effects on humans, this study unravels four active multi-target inhibitors against AChE with promising affinities and good ADMET profile for the potential use in AD treatment.

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Requirement's elicitation is the process of gathering requirements from users, customers, and stakeholders using traditional or collaborative elicitation techniques. Software requirement gathering is a challenging task particularly in a Global Software Development (GSD) paradigm due to geographical distance, limited face to face meetings, time zone differences, and language and cultural barriers. As more companies begin to adopt GSD in order to save costs, the success factors need to be identified and evaluated in order to ensure a successful elicitation process. This paper offers an in‐depth analysis on success factors for requirement elicitation within GSD environment. First, all possible success factors are identified from the literature via a Systematic Literature Review (SLR). Next, these factors are evaluated by software industries via a questionnaire survey across different types and levels of experts, size of organizations, and from the client–vendor perspective. The relationships between the success factors and the survey results were evaluated using the Spearman's correlation coefficient. The results produced a 0.835 Spearman's correlation coefficient at significance level ρ = 0.000, which showed a strong positive correlation between the outcome of SLR and survey with no significant difference.

Information Technology has brought significant changes to the human social interaction & behaviors. Behavioral addiction to social media use is a rather novel concept in psychiatric “classification of diseases”. Some foreign studies have reported it to be as high as 29.5%.7,8 There is need to study this relatively neglected area specially among our youth. This will help provide reliable data to understand the magnitude of current problem. Objectives: To study the Components of Behavioral addiction to Social Media use: Conflict, Mood Modification, Relapse, Salience, Tolerance and Withdrawal, among the youth in Pakistan. Study Design: Cross-sectional study. Setting: Department of Psychiatry Services Institute and Medical Sciences, Lahore. Period: March 2019 to May 2019. Material & Methods: Among University students was conducted Purposive sampling technique was employed. Questionnaire forms were given to students of a University. Each questionnaire had 12 questions. There were specific questions for each component of addiction: Conflict, Mood Modification, Relapse, Salience, Tolerance and Withdrawal. Each respondent’s bio-data, preferred social networking medium and frequency of social media use were recorded. They were also asked about their perception about excessive social media use. The responses were based on Likert scale. The respondents were asked to give the single best response to each question. A total of 210 responses were obtained. They were assessed using the software, IBM SPSS version 25. Results: The sample population reported positive for all the components of addiction tested. The majority (greater than 50%) of responses for each component were in “Always” to “Sometimes” range of Likert scale. Conclusion: The current generation of Pakistani youth might be suffering from Behavioral Addiction to Social Media use.