Lymphocyte m at ant factor (LCF) is a lymphocyte cell product that mulat a m y response in CD4+ lymphoyte ocytes, and eopls. (3,10). These prior studies suggested that LCF-mediated events might occur following interaction of LCF with CD4 or a CD4-associated molecule.In this report we describe the molecular cloning of cDNA encoding human LCF and its expression in recombinant form (rLCF).t It is an unusual lymphokine with no significant homology to any previously described cytokines. We identify the requirement for rLCF autoaggregation to induce bioactivity and demonstrate a direct correlation between surfaceexpressed CD4 and LCF-induced migration. In addition, our data suggests that CD4 functions to transmit the migratory signal induced by rLCF. MATERIALS AND METHODSCells. Human peripheral blood mononuclear cells (PBMC) were isolated as described (1)(2)(3) Murine T-Cell Hybridoma Cell Lines. Three murine T-cell hybridoma cell lines were established as described (13,14

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Introduction: COVID-19 has significantly decreased the influx of patients presenting with dermatologic diseases at hospitals due to lockdown and restrictions pertaining to stop the spread of COVID-19. Objective: To describe the effect of changes of COVID-19 on the clinical spectrum of patients presenting in dermatology OPD at a tertiary care unit in Rawalpindi, Pakistan. Method: A comparison of the census of the dermatology outpatient department of three corresponding months before and after COVID-19 was done. During the pandemic year (2020) a significant decrease in patients visiting the dermatology outpatient department was observed. Results: This reduction was much more prominent for the extreme of ages i.e. children and elderly. Infections and infestations were the predominant causes of presentation of patients at our dermatology outpatient department in pre-COVID-19 as well as during the pandemic. Patients with serious dermatologic conditions (e.g., pemphigus vulgaris, erythroderma, and cellulitis), however, had significantly fewer visits during the pandemic as compared to Pre COVID-19 era. In contrast, patients suffering from eczema constituted a significantly higher rate of outpatient visits during the pandemic. Conclusion: Patients with serious dermatologic conditions (e.g., pemphigus vulgaris, erythroderma, and cellulitis), had significantly fewer visits during the pandemic as compared to the Pre COVID-19 era. In contrast, patients suffering from eczema constituted a significantly higher rate of outpatient visits during the pandemic.

Cavernous hemangiomatous polyp of uterus is a rare vascular malformation of the uterus. Common sites of malformation in uterine wall include serosa, myometrium, and endometrium and most common presentation is diffuse involvement of uterus. Patients usually present with obstetric and gynecological complications ranging from menorrhagia, intermenstrual bleeding, infertility, and pregnancy-associated complications which includes maternal and fetal demise due to excessive bleeding. Uterine hemangiomas occur at all age groups without preponderance in any decades and are classified into congenital and acquired. Congenital hemangiomas may be associated with hereditary diseases whereas acquired hemangiomas are thought to be associated with both physical changes and hormone alterations.