We describe three patients with early onset of parkinsonism. Two of these were sisters and showed a reduction in homovanillic acid (HVA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) levels in the CSF. In the third patient, parkinsonism developed, which was probably related to chickenpox encephalitis. All three patients responed favorably to levodopa therapy.

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Reversible cerebellar dysfunction is described in a patient with primary hemochromatosis. The electroencephalographic abnormalities initially recorded became normal after repeated phlebotomies. Both cerebellar dysfunction and electroencephalographic changes were present without clinical signs of hepatic failure, but may be related to the altered hepatic function tests.

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