Purpose: To assess the analgesic role of neuroleptics in hyperglycemic state.Methods: Amytryptiline and carbamazepine were selected for study. This study was carried out at Pharmacology lab, Institute of Research Pharmaceutical sciences, University of Karachi, and comprised of male and female mice, half of which were made diabetic by giving Alloxan. The objective of this study is to monitor the effects of neuroactive agents on analgesic activity in hyperglycemic mice. Results:It was observed that Amytryptiline exhibited highly significant analgesic effect in normal as compared to diabetic subjects. It was also observed that both amytryptiline and carbamazepine produce more rapid onset of action and longer duration of action in normal animals when compared with diabetic animals. Conclusion:The present work on normal and diabetic animals show that both Carbamazepine and Amytryptiline in normal animals produce rapid onset and longer duration of action when compared with diabetic animals.