Pentazocine is a synthetic, narcotic analgesic, indicated for various moderate-to-severe pain conditions. Its use and dependence on health care personnel pose unique challenges that make them difficult in seeking help. Complications due to parenteral pentazocine injection resulted in significant impairment for day-to-day functioning and contribute to disability. Hence, we present a case series on pentazocine dependence in health care personnel along with chronic nonhealing ulcers, myofibrosis, inflammatory compartmental syndromes like puffy hand syndrome and highlighting the integrative management of it.

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