Nizatidine is a histamine H2 receptor antagonist. This compound belongs to the class of organic compounds known as 2,4‐di‐substituted thiazoles. These are the compounds containing a thiazole ring. It inhibits the action of histamine mediated by H2 receptors such as gastric acid and pepsin output and the drug is used for the treatment of duodenal ulcers. This review presents an overview about the different analytical methods for the analysis of Nizatidine and its metabolite in biological fluids, commercial products, and simultaneous estimation of other H2 receptor antagonist in commercial products. The most commonly used analytical method for Nizatidine is high‐performance liquid chromatography. This review also gives information about pharmacokinetics, its application and susceptibility of H2 receptor antagonist to metabolism by gastrointestinal flora.

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