Vesicular system brings several possible advantages over conventional route of drug delivery system. Formulation of system to administered via transdermal is an attractive option because this route is suitable and safe. Transfersomes is one of vesicular system which possesses a single chain surfactant as it offers ultra deformation property which provides better penetration. Vesicles of hydrophobic and hydrophilic moieties can be formulated together and as a result can deliver drug molecules with wide range of solubility. Problems of drug leakage and low entrapment could be overcome in this system. Materials which are widely used in the formulation of it are various phospholipids, surfactants, alcohol, dye and buffering agent. These systems can deform up to 5 times lesser than its original size to pass through narrow constriction without showing drug leakage. These are more flexible and adjustable than that of liposomes thus can be used to carry drugs across the biological membrane, such as skin. It can act as a carrier for wide variety of drugs.

Main objective behind formulating any dosage form is to develop the optimized and stable dosage from which will releae the drug fastly in conventional formulations. Various approaches such as, solid dispersion, crystal engineering, ball milling, complexation, and self-emulsifying drug delivery systems have all been used in recent research to increase the solubility of the drug, but the liquisolid compact has demonstrated superior results for enhancing dissolution. In most of the cases absorption of drug is less which is due to various factors one of the most important factor is drug solubility. Liquisolid compacts are a novel and promising addition to such a novel goal because the liquisolid technology has been successfully used to treat low-dose poorly soluble drugs. A thiazolidinedione, pioglitazone HCl is primarily prescribed to type 2 diabetics as an antihyperglycemic medication. Compared to traditional carrier materials, Neusilin US2 performs better as a carrier material in liquisolid compact. Drugs from BCS Class II can be easily formulated using liquisolid compact by the simple blending method. A drug having a low dose can be formulated by this method.