Synthesis of title compounds (4a-j) was carried out by following aminomethylation Mannich reaction. Test compounds were effective in inhibiting edema induced by carrageenan. The percent inhibition obseved was in the range of 25-83.3%. Compound (4c, e, h and j) were also tested for analgesic effect and showed percent protection ranging between 57-65%. All the synthesized compounds were active against E. coli and S. aureus but only compounds (4 b, c, e, i and j) were active against B. subtilis. All these compound were also found active against A. niger. Compound 4j was the most active compound with 83.3% inhibition of edema, 65.35% percent protection and inhibited all the three bacterial strains.

No abstract

A series of some new benzoxazines derivatives have been synthesized using conventional method and solvent-free microwave thermolysis. It was observed that the solvent-free microwave thermolysis is a convenient, rapid, high-yielding, and environmental friendly protocol for the synthesis of benzoxazines when compared with conventional reaction in a solution phase. All the compounds synthesized were tested for anti-inflammatory activity. Compound 3f, 3h, and 3l showed 74.87, 70.39, and 71.89% of inhibition in rat paw edema, 57.38, 54.27, and 55.47% of protection against acetic acid induced writhings, and 0.08, 0.17, and 0.17 of severity index (SI), respectively compared to 82.33, 63.06, and 1.0 values of ibuprofen. The study showed that these compounds are good and safe anti-inflammatory agents and can be used to develop potent and safe anti-inflammatory agents.