The data were collected by a structured questionnaire including age, socioeconomic condition, gravida, para , blood pressure, BMI, FBS, PPBS & Family H/O diabetes mellitus. Patients suffering from shortened red blood cell life span, sickle cell disease or any other condition that could result in premature red blood cell death and longer red blood cell life span, such as vitamin B12 or folate deficiency were excluded. Total 110 pregnant women were included in this study. Among them 70 were considered as case (whose FBS &PPBS according to ADA criteria of FPG value of ³5.3mmol/l and the WHO criteria of a 2-h PPPG value of ³7.8mmol/l) and 40 were considered as control (whose FBS <5.3mmol/L & PPBS <7.8mmol/L). HbA 1c were measured in all sample. Results: Study showed that HbA 1c ( 6%) were more increased in GDM patients than that of the normal pregnancy ( (6.95±1.38% Vs 5.05 ±0.27 %, p<0.001).Result showed that percentage of raised plasma HbA 1C is more in GDM patients than that of the normal pregnancy (57.1%,P=<0.001).Pearson

Background: Polycystic Ovarian Syndrome (PCOS) is common but a treatable cause of infertility in reproductive women. Thyroid hormone abnormality is commonly seen in Polycystic Ovarian Syndrome of reproductive women. Antithyroid antibodies have been detected in women with PCOS. The aim of the present study is to evaluate the antithyroid antibodies in Polycystic Ovarian Syndrome (PCOS) of reproductive women. Materials and methods: A hospital based cross-sectional comparative study was conducted in the outpatient Department of Obstetrics and Gynaecology in CMCH, Institute of Nuclear Medicine and Allied Subject and the Department of Biochemistry in CMC. Eighty (80) PCOS women diagnosed by ultrasonography were taken by nonprobability convenient sampling, considered as group A and another twenty (20) healthy women were taken, considered as group B. Important variables in this study were serum anti-TPO antibody, anti-Tg antibody, TSH, age, menstrual history, hirsutism, waist circumference and BMI. Results: This study revealed a statistically significant higher prevalence of autoimmune thyroiditis in PCOS cases in comparison to healthy group (32.5 % and 37.5% patients had increased anti-TPO and anti-Tg antibodies respectively). Mean serum anti-TPO and anti-Tg antibodies were increased significantly in PCOS cases than that of healthy women group. Mean serum TSH was not increased significantly in PCOS cases than that of healthy group.52.5%, 47.5% patients had oligomenorrhea and amenorrhea respectively, 21.2% had hirsutism, 68.8% cases were overweight & obese and 77.5% were central obese.  Conclusion: High prevalence of thyroid autoimmunity in euthyroid PCOS patients refers to the importance of screening not only thyroid hormone levels but also thyroid antibody level during the investigation of PCOS of reproductive women and thereby early diagnosis and management of infertility associated with PCOS. JCMCTA 2021 ; 32 (2) : 105-110

Background: Lung function varies with the different body posture of normal individuals. Normal healthy school children adopt different body posture which influences their lung function. This cross sectional observational study was done to assess the effects of different sitting postures on lung function like forced vital capacity (FVC) in healthy school children. Methods: This study was conducted in the Department of Physiology, Chittagong Medical college, Chittagong and K S Nazu Miah High school, Khondokia, Younus Nagar, Hathazari, Chittagong during July 2015 to June 2016. A total of 88 subjects of which 42 male and 46 female students aged between 14-16 years studying in class eight to ten were included by purposive sampling method. FVC were recorded by portable digital spirometer (HI-101, Japan). Data were taken in normal upright sitting, kyphotic and at slumped sitting posture. Unpaired and paired t test and repeated measure ANOVA tests were done using SPSS for windows version 20. Results: The mean value of FVC were significantly (p<0.001) changed in different sitting posture. Kyphotic sitting posture showed no significant difference (p>0.05) comparing to normal upright sitting posture. Regarding slumped sitting posture comparing to normal upright showed significant low values (p<0.001). Female subjects showed significant low FVC (p<0.001) comparing to male subjects. Conclusion: The results of this study suggest that the lung function like FVC is significantly decreased in slumped sitting posture. Bangladesh Med Res Counc Bull 2019; 45: 117-121

Plasma fibrin degradation products (F.D.P.) assay measures the amount of fibrin split products in the blood. The high levels of F.D.P. in pre-eclampsia suggests that abnormal amount of degradation products are most likely due to localized lysis of fibrin in the uterine vascular compartment. The present case control study was designed to determine the relationship between plasma fibrin degradation products and pre-eclampsia. The study was carried out in the department of Biochemistry, Chittagong Medical College during the period of September 2011 to August 2012. The samples were collected from the department of Obstetrics and Gynecology, Chittagong Medical College Hospital, age from 18- 40 years. The data were collected by a structured questionnaire including age, socioeconomic condition, gravida, para, edema, blood pressure, proteinuria, history of hypertension, family history of pre-eclampsia and diabetes mellitus. Considering the cost of experiment and length of time, total 60 patients were included in this study. Among them 40 were considered as case (Blood Pressure > or = 140/90 mm of Hg and proteinuria > 0.3 gram/day) and 20 were considered as control (Blood Pressure < 140/90 mm of Hg and no proteinuria). Plasma fibrin degradation products were measured in all samples. Study showed that plasma FDP were more increased in pre-eclamptic patients than that of normal pregnancy (21.52 + 16.47 ugm/ml Vs 10.63 + 7.12 ugm/ml), P = <0.01. Result showed that percentage of raised plasma FDP is more in preeclamptic patients (100%) than that of normal pregnancy (75%), P= <0.01. Pearson's Correlation Coefficient (r) showed that there were positive correlation between blood pressure and plasma FDP (systolic blood plessure and plasma FDP, r=0.221,P=>.0.05 and diastolic blood pressure and plasma FDP, r=0.285,P=<0.05). Significantly raised level of plasma F.D.P. in pre-eclampsia help to formulate a management plan and thereby reduce the complications of this disease. JCMCTA 2013; 24 (1):9-13

Background : Vitamin D is an essential nutrient and deficiency of it leads to devastating disorders. This study aimed to find out the associated factors with selected variables of low vitamin D among adult females of Chattogram. Materials and methods : Cross-sectional observational study was conducted from September 2019 to February 2020 at a diagnostic complex of Chattogram. Participants were adult females of Chattogram. All participants gave oral informed consent and answered a questionnaire that included 16 questions covering demographic information, monthly income, educational status, occupation, body weight, duration of sun exposure, dress pattern (Using hijab or burkha, regular dress-up) drug and disease history. Blood samples were collected by cautious aseptic procedure. Serum vitamin D levels were measured by using immunoassay method. Adult females of Chattogram with no religious restrictions, n= 150,aged 31 to 70 years. Results: Overall, 88% had low vitamin D levels with deficient 60.66% and insufficient 27.34%. Sufficient level of vitamin D was found only among 12%. The prevalence of vitamin D deficiency was much higher in females with house-wife status 73.33% (p value of 0.0001) wearing hijab 46.66% (p value of 0.001). It could be due to interference with UVB radiation into skin, short duration of sun exposure, use of sunblock cream or less supplementary intake. Conclusion : Vitamin D deficiency is an emerging but neglected health issue in modern time, particularly more vulnerable are female population. Ironically, abundant sunlight of Bangladesh seems failed to protect the self-imposed concrete prisoner, classically known as home-makers, and practitioner of indoor life style that leads to avoidance of sun light. However, large sample size is mandatory to boost-up the findings of current study. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 74-78