Oxidative stress may play a pivotal role in the pathogenesis of psoriasis, an inflammatory/hyperproliferative skin disease characterized by the cutaneous accumulation of neutrophils releasing reactive oxygen species, as revealed in a number of studies. This study was performed to demonstrate the presence of oxidative stress in psoriasis, as measured by protein oxidation markers. Twenty-nine psoriasis patients were selected based on disease severity assessment using body surface area as well as the psoriasis area severity index (PASI), and were grouped as mild (PASI ≤ 10) and moderate-to-severe (PASI > 10). The measured parameters in psoriatic patients and fourteen healthy volunteers were as follows: erythrocyte sedimentation rate (ESR), high sensitive C-reactive protein (CRP), myeloperoxidase (MPO) activity, neopterin, total lipid hydroperoxides (LHP), pyrrolized protein (PP), protein carbonyl compounds (PCC), advanced oxidation protein products (AOPP), thiol levels, along with complete blood count. Except lower thiols, all parameters were found to be higher in total patients as well as in subgroups, compared to controls. There was no significant difference among the subgroups. In conclusion, protein oxidation in psoriatics, not only in moderate-to-severe, but also in mild patients, may be explained by the findings of inflammation, phagocytic cell oxidation, and MPO-hypochlorous acid-oxidation reactions; as reflected by increased total/differential leucocytes counts, CRP, ESR as well as MPO, neopterin, AOPP, PCC, PP, LHP, and decreased thiol levels. Demonstrating the AOPP and PP formation for the first time, oxidants from active neutrophils/monocytes may play an important role in the pathogenesis of psoriasis, leading to oxidative stress, especially by protein oxidation.

Melkersson-Rosenthal syndrome is a rare condition characterized by a triad of orofacial edema, facial paralysis, and fissured tongue. Histopathological examination of the disease has demonstrated areas of inflammation involving mast cells. Activated mast cells also play a part in the pathogenesis of COVID-19 infection, as they release cytokines in the lungs. We present a case of a female patient presenting with edema. We present a case of a female patient presenting with edema. Her examination revealed edema in the right lower lip, right facial paralysis, and fissured tongue. COVID-19 may be associated with which was not previously included in the etiology of the disease.

Coronavirus disease, first emerged in Wuhan, rapidly spread all over the world since December 2019. There are concerns about elective dermatology appointments and its results. Herein, we aimed to find out which type of dermatologic patients attended to dermatology outpatient clinic. The patients visiting the clinics for elective dermatologic diseases between March 11 and 18, 2020, were included in this study.Their age, sex, diagnosis of disease, requirement for emergent intervention, and their

Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of leishmania protozoan parasites. Lupoid CL is a rare form of CL that has a stunning similarity to other granulomatous cutaneous conditions of infectious or inflammatory origin. Verruca plana, also known as a “flat wart”, is a benign proliferation of the skin resulting from infection with human papilloma virus (HPV). Herein, we presented a case of lupoid CL mimicking verruca plana on the face.

ÖzetEozinofilik pannikülit subkutan dokuda daha çok eozinofillerin oluşturduğu mikst tipte iltihabi hücre infiltrasyonu ile seyreden bir pannikülittir. Etiyolojide en sık gnathostomiyazis (Larva migrans profondus), lökositoklastik vaskülit ve eritema nodosum suçlanmaktadır. Burada steroid tedavisine yanıt alınamayan ancak dapson tedavisi ile tam olarak düzelen idiyopatik eozinofilik pannikülitli bir olgu sunularak literatür bilgileri gözden geçirilmiştir. (Turk J Dermatol 2010; 4: 94-6 GiriEozinofilik pannikülit, subkutan ya dokusunun yo un olarak eozinofillerden olu an infiltrasyonudur. Klinik olarak genellikle eritemli subkutan nodüller eklinde kar mza ç kmaktad r. Baz hastal klarla birliktelik bildirilmektedir (1). Burada, altta yatan herhangi bir neden tespit edilemeyen ve dapson tedavisine yan t al nan bir olgu literatür bulgular e li inde sunulmaktad r. OlguElli ya nda erkek hasta, be y ld r y lda bir kaç kez tekrarlayan kol ve bacaklarda k zar kl k, i lik ikâyetiyle klini imize ba vurdu. i likler yakla k 20 gün devam edip kendili inden geçiyormu . Dermatolojik muayenesinde; sa kol, sol uyluk ve bacakta eritemli 5-6 cm çap nda nodüler lezyonlar tespit edildi ( ekil 1).Al nan deri biyopsisinde yüzeysel dermiste perivasküler mononükleer hücre infiltrasyonu, subkutan ya doku içerisinde nodüler ve lobüler yer yer septal yerleim gösteren bask n olarak eozinofilleri ayr ca nötrofil ve histiyositleri de içeren mikst tipte iltihabi hücre infiltrasyonu izlendi ( ekil 2). Bulgular eozinofilik pannikülit ile uyumlu olarak de erlendirildi.Hastan n tam kan say m nda hemoglobin: 16.8 g/dl, beyaz küre: 6530 hcr/ L, trombosit: 175.000 /L, kan biyokimyas nda üre: 23.5 mg/dl, kreatinin: 0.9 mg/dl,