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: Natural products, an infinite reserve of bioactive molecules, will continue to serve humans as an important source of therapeutic agents. Germacrone is a bioactive natural compound found in the traditional medicinal plants of family Zingi-beraceae.This multifaceted chemical entity has become a point of focus during recent years due to its numerous pharmaco-logical applications e.g., anticancer, anti-inflammatory, antiviral, antioxidant, anti-adipogenic, anti-androgenic, antimicrobi-al, insecticidal, and neuroprotective properties. Germacrone is an effective inducer of cell cycle arrest and apoptosis in vari-ous cancers (breast, brain, liver, skin, prostate, gastric, and esophageal)viamodulation of different cell signaling molecules and pathways involved in cancer proliferation. This is the first report highlighting the wide spectrum of pharmacological ac-tivities exhibited by germacrone. The reported data collected from various shreds of evidences recommend that this multi-faceted compound could serve as a potential drug candidate in the near future.

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