Graphene oxide nanosheet catalyzed strategies for construction of 2,3-dihydroquinazolinones and quinazolin-4(3H)-ones starting from anthranilamide and an aldehyde/ketone in aqueous medium at room temperature have been realized.

Metal free green protocol in aqueous medium. Use of GO nanosheets as exclusive heterogeneous catalyst. Almost intact catalytic activity upto the 5th run. Mild reaction conditions preserve sensitive structural moeities.

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Graphene Oxide nanosheets were found to be a highly efficient, reusable and cost-effective carbocatalyst for the facile synthesis of highly diversified 4H-pyrans via one-pot, two-component condensation reaction between freshly prepared chalcones and 4hydroxycoumarin in aqueous media offering excellent yields. The new, green and metal free synthetic method also enables the condensation reaction for the formation of a library of pyranoquinolines and pyranopyrans 15

A catalyst-free green methodology for the synthesis of pharmacologically important spirooxindole derivatives has been developed by a three-component domino reaction between isatin, various amino compounds, and 1,3-dicarbonyl or 3-phenylisoxazolone compounds in ethyl L-lactate medium at room temperature. This new efficient synthetic method facilitated the formation of a wide range of biologically significant spirooxindole derivatives (including 17 new spirooxindoles) under very mild conditions. The cytotoxic activity of one of the isoxazole-fused spirooxindoles was evaluated in MDA-MB 468 breast cancer cell line. It was found that cell survivability decreases with increasing concentration of the selected compound in MDA-MB 468 breast cancer cells.