Coronary artery disease (CAD) is a caused by atherosclerotic plaque buildup in the coronary arteries that supply blood and oxygen to the heart. Matrix metalloproteinase (MMP) is a family of zinc-dependent endopeptidase that is involved in various stages of atherosclerosis as demonstrated in in vitro and in vivo studies. MMP-2 is associated with both stable and unstable atherosclerotic plaque formation. The current review aimed to identify the role of MMP-2 in atherosclerosis development among CAD patients. Literature search was conducted through four online databases and only studies that were published from 2018 until February 2023 were included. The risk of bias was assessed by using the Newcastle–Ottawa Scale. A total of 10,622 articles were initially identified, and only eight studies that fulfilled the selection criteria were included in this review. The results showed that MMP-2 levels and activity were higher in patients with unstable CAD than those with stable CAD and healthy subjects. There was a significant association between MMP-2 levels and cardiovascular disease with MMP-14 levels, which is a pro-MMP-2 activator. In addition, two single nucleotide polymorphisms of the MMP-2 gene (rs243865 and rs243866) were significantly associated with the development of atherosclerosis. In conclusion, MMP-2 plays a crucial role in the development of atherosclerosis among patients with CAD and could be a potential target for CAD therapy.

Review question / Objective: The aim of the study is to determine the role of MMP-2 in a t h e ro s c l e ro s i s p ro g re s s i o n a m o n g patients with CAD. P: Patients diagnosed with CAD. I: MMP-2 involvement in atherosclerosis and expression in CAD patients. C: Compared with healthy group. O : M M P -2 a r e a s s o c i a t e d w i t h atherosclerosis progression among CAD and its expression level is higher in CAD. S: Human study. Rationale: 1) The prevalence of coronary artery disease (CAD) is increased. 2) MMP-2 was found to be involved in all stages of atherosclerosis process, the main pathogenesis of CAD through invitro and invivo studies. 3) There is a lack of studies INPLASY 1 International Platform of Registered Systematic Review and Meta-analysis Protocols INPLASY PROTOCOL Role of matrix metalloproteinase-2 among coronary artery disease (CAD) patients: A systematic review Samah, N 1 ; Ugusman, A 2 ; Hamid, AA 3 ; Sulaiman, N 4 ; Aminuddin, A 5 . To cite: Samah et al. Role of matrix metalloproteinase-2 among coronary artery disease (CAD) patients: A systematic review. Inplasy protocol 202340058.