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We discuss the pathology perspective in the manuscript titled "The efficacy and safety of endoscopic ultrasoundguided liver biopsy versus percutaneous liver biopsy in patients with chronic liver disease: a retrospective singlecenter study" [1]. In this study, the safety and efficacy of liver biopsies performed by endoscopic ultrasound (EUS-LB) were compared with those performed via the traditional percutaneous route at our Medical Center between January 2018 and August 2019. The main findings of this study were EUS-LB was found to be safe and associated with less pain, shorter hospital stay, and high diagnostic yield (93%) compared to PC-LB. In this review paper, we would like to discuss our published paper and provide an in-depth discussion on the pathology perspective of EUS-LB and its diagnostic yield.

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