Purpose: Computed Tomography (CT) imaging is one of the most influential diagnostic methods. In clinical reconstruction, an effective energy is used instead of total X-ray spectrum. This approximation causes an accuracy decline. To increase the contrast, single source or dual source dual energy CT can be used to reach optimal values of tissue differentiation. However, these infrastructures are still at the laboratory level, and their safeties for patients are still yet to mature. Therefore, computer modelling of DECT could be used. Methods: We propose a novel post-processing approach for converting a total X-ray spectrum into irregular intervals of quantized energy. We simulate a phantom in GATE/GEANT4 and irradiate it based on CT configuration. Inverse Radon transform is applied to the acquired sinogram to construct the Pixel-based Attenuation Matrix (PAM). To construct images represented by each interval, water attenuation coefficient of the interval is extracted from NIST and used in the Hounsfield unit (HU) scale in conjunction with PAM.

Reference 1 Lee JK, Kang HW, Kim SG, Kim JS, Jung HC. Risks related with withholding and resuming anticoagulation in patients with non-variceal upper gastrointestinal bleeding while on warfarin therapy. Int J Clin Pract 2012; 66: 64-68.

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