Women with Loeys-Dietz syndrome warrant special consideration in obstetric management secondary to the risk for aortic dissection. It is recommended that a multidisciplinary team with knowledge about connective tissue disorders and expertise in aortic surgery coordinate maternal obstetric and cardiovascular care.

OBJECTIVE: Preeclampsia (PreE) is a hypertensive disorder of pregnancy afflicting 5-10% of US pregnancies. Recent reports suggest 20hydroxyeicosatetraenoic (20-HETE) may play a role in hypertension in response to placental ischemia. We hypothesized that administration of a 20-HETE synthesis inhibitor, HET0016, would improve the pathophysiology associated with PreE in the RUPP rat model of placental ischemia.Poster Session III ajog.org