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Summary A Children’s Oncology Group clinical trial aimed to determine if bortezomib (B) increased the efficacy of ifosfamide and vinorelbine (IV) in paediatric Hodgkin lymphoma (HL). This study enrolled 26 relapsed HL patients (< 30 years) treated with 2–4 cycles of IVB. The primary endpoint was anatomic complete response (CR) after 2 cycles. Secondary endpoints included overall response (OR: CR + partial response) at study completion compared to historical controls (72%; 95% confidence interval [CI]: 59–83%). Although few patients achieved the primary objective, OR with IVB improved to 83% (95% CI 61–95%. p=0.32). Although not statistically different, results suggest IVB may be a promising combination.

Ein koordinativ ungesättigter Ruthenium(II)‐Komplex reagiert mit einem (Alkenylvinyl)cyclopropan zum ersten Cyclodecadienyl‐Ruthenium‐Komplex (siehe Schema; nicht spezifizierte Koordinationsstellen am Rutheniumzentrum können durch das Solvens (Aceton) oder Acetonitril besetzt sein). Diese beispiellose, mechanistisch interessante Reaktion macht auf präparative Anwendungen neugierig.

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