Anaphylaxis is a potentially life-threatening allergic reaction. Virtually all vaccines have the potential to trigger anaphylaxis. There are cases reported with mild systemic reaction but anaphylactic shock after anti-rabies vaccination is rare. Side effects due to allergic reaction to vaccine antigen or the additives have been known for some time. Most of the cases are acute and only few with delayed hypersensitivity are shown to have cell mediated immune response. Once adverse effects occur immediate medical treatment and appropriate change of vaccine and vaccination schedule are of significance.