Fused pyrimidine derivatives R 0515Novel Synthesis and Biological Activity Study of Pyrimido[2,1-b]benzothiazoles. -10 Title compounds are prepared and screened for their antimicrobial and antifungal activities. (IIIa), (IIId), and (IIIf) show good activity against Candida albicans and (IIIf) also against Staphylococcus aureus. -(GUPTA*, S.; AJMERA, N.; GAUTAM, N.; SHARMA, R.; GAUTAM, D. C.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 6, 853-857; Dep. Chem., Univ. Rajasthan, Jaipur 302 004, India; Eng.) -M. Bohle 42-166

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10H‐phenothiazines are synthesized via Smiles rearrangement. These prepared phenothiazines act as a base to prepare ribofuranosides by treating them with b‐D‐ribofuranosyl‐1‐acetate‐2,3,5‐tribenzoate. 10H‐phenothiazines on refluxing with hydrogen peroxide in glacial acetic acid gave 10H‐phenothiazine‐5,5‐dioxides. The synthesized compounds were evaluated for their antioxidative properties through in vitro studies, and they are also screened for their antimicrobial activity. The structure of the synthesized compounds has been established by elemental analysis and spectroscopic data.

This article describes the synthesis of new substituted 10 H-phenothiazines by Smiles rearrangement. These compounds are then used as a base to form ribofuranosides by treating them with a sugar (1-O-acetyl-2,3,5-tri-O-benzoyl-beta-ribofuranose). On oxidation with hydrogen peroxide in glacial acetic acid, these phenothiazines yield their sulfones. These compounds are screened for antioxidant and antimicrobial activity and their structure has been established by elemental analysis and spectroscopic data.