One of the most difficult and elusive goals of Periodontics in the field of reconstruction and regeneration is the surgical reconstruction of the lost interdental papilla. This clinical and aesthetic dilemma demands more attention from the clinician. Several non-surgical and surgical techniques have been proposed to manage the interproximal space. Non-surgical approaches modify the interproximal space and the surgical techniques aim to re-contour, preserve and reconstruct the soft tissue between the teeth. Platelet rich fibrin has been extensively used in hard and soft tissue augmentation, but not tried for augmenting interdental papilla. The purpose of this case series is to describe a novel approach of papilla reconstruction in the maxillary anterior region with the use of platelet rich fibrin. This procedure obtained optimal fill in all the cases postoperatively. Thus, the use of PRF may be the panacea for interdental papilla augmentation.