Objective:Transformed mycosis fungoides (T-MF) is a rare variant of MF with an aggressive course. In this study, we aimed to describe characteristics of MF/Sezary syndrome (SS) patients with transformation.Materials and Methods:Patients diagnosed with T-MF among MF/SS patients between 2000 and 2014 in a tertiary single center were evaluated retrospectively. Demographic data, clinical data, laboratory data, immunophenotype features, response to treatment, survival, and histopathologic features were analyzed.Results:Among 254 MF patients, 25 patients with T-MF were identified (10.2%) and included in the study. The male-to-female ratio was 2.6/1. The median time between MF diagnosis and transformation was 32 months (range: 0-192). Nine (36%) patients were diagnosed initially with T-MF. Advanced disease stage and high serum lactate dehydrogenase (LDH) levels were indicators of poor prognosis and treatment response. Five of the 18 patients with progressive disease had undergone allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT resulted in complete remission in three (60%) patients. Ten (40%) patients died as a result of disease progression. Mean survival time was 25.2±14.9 (2-56) months after transformation.Conclusion:Advanced stage, high serum LDH levels, and loss of CD26 and CD7 expression in the peripheral blood are poor rognostic factors in T-MF. Treatment-resistant tumors and nodules should be cautionary for T-MF. Patients with T-MF have a shortened survival. Some patients may respond to first-line treatments. However, the majority of patients who do not respond to first-line therapies also are unresponsive to second or third-line therapies. Allo-HSCT may be an alternative option in patients with T-MF.

These two treatment protocols were not superior to each other in terms of cumulative NB UVB dose, efficacy, total number of treatment sessions, and side effect profiles.

Chemical matricectomy with sodium hydroxide is an easy method in the treatment of ingrown nails, with low morbidity and high success rates. There was no difference between 1-minute and 2-minute applications in terms of recurrence during the long-term follow-up. Chemical matricectomy with 1-minute application of sodium hydroxide showed high success in terms of long-term follow-up results.

Objective: Isotretinoin is widely used in severe acne treatment. The drug leads to several adverse effects; skin and mucous membranes are frequently affected. It may also cause serious and fatal adverse effects like kidney damage. The aim of this study is to determine the safety of isotretinoin usage on kidney functions in patients with acne vulgaris. Methods: Eighty six patients with severe acne vulgaris and receiving 0.5 mg/kg/day of isotretinoin treatment were included in the study and evaluated retrospectively. Serum urea, creatinine, complete blood count, aspartate aminotransferase, alanine aminotransferase, lipid profile datas were obtained from patient files. Glomerular filtration rate (GFR) was measured at the baseline of treatment, 3 rd and 6 th months of treatment. Results: We detected significant increases in levels of creatinine on the third month (p=0.041), but it was not clinically significant, and there was no significant difference in creatinine levels at 6 th month. There were no significant differences among the baseline, 3 rd month (p=0.066) and 6 th month (p=0.429) of GFR values. Conclusion:We think that isotretinoin is safe for the kidneys but patients with high creatinine levels at the baseline of treatment should be closely followed up.Amaç: Şiddetli akne tedavisinde isotretinoin yaygın olarak kullanılmaktadır. İlaç çok sayıda yan etki oluşturmaktadır; deri ve mukoz membranlar ise sıklıkla etkilenmektedir. Ayrıca böbrek hasarı gibi ciddi ve ölümcül yan etkiler de görülebilmektedir. Bu çalışmanın amacı, akne vulgarisli hastalarda isotretinoin kullanımının böbrek fonksiyonları üzerindeki güvenilirliğini değerlendirmektir. Yöntemler: Şiddetli aknesi olan ve 0,5 mg/kg/gün isotretinoin tedavisi alan 86 hasta çalışmaya alındı ve geriye dönük değerlendirildi. Serum üre, kreatinin, tam kan sayımı, aspartat aminotransferaz, alanin aminotransferaz, lipit profil verileri hasta dosyalarından elde edildi. Glomerüler filtrasyon hızı (GFR) tedavi başlangıcında, tedavinin 3. ve 6. ayında hesaplandı. Bulgular: Tedavinin 3. ayında kreatinin değerlerinde anlamlı artış gözlendi (p=0,041); ancak klinik olarak anlamlı değildi, tedavinin 6. ayında ise kreatinin değerlerinde anlamlı farklılık yoktu. Başlangıç, 3. ay (p=0,066) ve 6. ay (p=0,429) GFR değerleri arasında anlamlı farklılık görülmedi. Sonuç: İsotretinoinin böbrekler için güvenilir olduğunu düşünüyoruz; ancak tedavi başlangıcında kreatin değeri yüksek olan hastalar yakın takip edilmelidir. Anahtar kelimeler: İsotretinoin, akne vulgaris, kreatinin, üre, böbrek fonksiyonu, böbrek hastalığında diyet modifikasyonu Öz