The simple suspension method is a method of administering drugs via a feeding or gastrostomy tube, and it involves allowing tablets or capsules to be disintegrated and suspended in warm water at 55℃ without crushing. The present study evaluated the stability of two prodrugs suspended alone or in combination with an alkaline agent according to the simple suspension method. The study used two ester-prodrugs, acemetacin (AMT) and cefpodoxime proxetil (CPP), which are hydrolyzed at higher pH. Drug concentrations in the suspension were measured by high-performance liquid chromatography. AMT and CPP were not hydrolyzed when suspended alone, but decomposed under alkaline conditions with the addition of magnesium oxide (MgO). The AMT concentration decreased to 55.5％ and 38.9％ at 30 min and 60 min, respectively, whereas its active metabolite, indomethacin (IMT), increased from 0 to 90.7 µg/mL and 122.7 µg/mL at 30 and 60 min, respectively. The CPP concentrations with MgO were decreased to 47.9, 28.5, 20.8 and 12.7％ at 30, 60, 90, and 120 min, respectively. Therefore, AMT and CPP should not be administered in the simple suspension method in combination with an alkaline drug that increases the suspension pH.

Etil p-metoksisinamat (EPMS) merupakan senyawa utama aktif anti-inflamasi yang terdapat dalam rimpang kencur (Kaempferia galanga). Tujuan penelitian ini adalah  untuk mengembangkan sediaan gel yang mengandung EPMS dengan menggunakan kombinasi HPMC dan karbopol 940 sebagai gelling agent. Sediaan gel di buat dalam tiga formula F1, F2 dan F3 dengan variasi persentase kombinasi HPMC : karbopol 940 yang digunakan masing-masingnya adalah 0,4 : 0,4%, 0,5 : 0,5%, dan 1.0 : 0,5%. Masing-masing formula selanjutnya  dievaluasi  sifat fisik dan kimianya. Hasil evaluasi fisik menunjukkan bahwa secara organoleptis ketiga formula F1, F2 dan F3 memenuhi syarat sediaan gel, serta stabil ketika dilakukan  pengujian sentrifugasi dan cycling test. Formuala F2 merupakan sediaan terbaik dalam pembuatan sediaan gel EPMS. Evaluasi stabilitas kimia menunjukkan bahwa kadar EPMS dalam sediaan gel hari ke- 0, 7, 14, dan 21 berada dalam rentang 91–100%. Sediaan gel mengalami penurunan kadar EPMS masing-masingnya sebesar 9% (F1), 5% (F2) dan 6%, (F3).

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A pharmacy is a place where pharmacists do their pharmaceutical work, serving directly and responsibly for patients who need their professional services. One form of direct service is the provision of drug information and counseling. The purpose of this study was to describe the drug information services provided by pharmaceutical personnel in the South Tangerang area pharmacy for patients who redeemed prescriptions using antibiotics. Patient simulation method was used to collect data to 100 pharmacies that were randomly selected based on data in the city health office. Recommendations were obtained from the South Tangerang branch of the Indonesian Pharmacists Association while ethical clearance was obtained from the ethical committee of the Faculty of Medicine, University of Indonesia. The results of this study indicate that 85% percent of pharmaceutical personnel who provide drug information for simulated patients are non-pharmacists. The most widely conveyed drug information items were the frequency of drug use delivered by 82% of pharmacists, received by the intended use (61%) and time of use (44%). Not related to pharmacy officers who submit the following information: drug interactions and ways to prevent them, side effects of drugs and how to prevent them; food and drinks that must be avoided as well as how to store drugs. As many as 51% of pharmacists provide additional antibiotics requested by patients without a prescription. Drug information points provided by pharmacy staff specifically  by pharmacist had not been maximally delivered.

Abstract; Pharmacy profession (pharmacist) is one of the health profession which has high responsibility for the patient health and safety. In doing this responsibility, a pharmacist should serve their patient directly. Anybody who choose the profession should aware and run it with all their heart and sincerely. This study aimed to describe the perception of fourth year pharmacy student toward the pharmacy profession that they choose. A questionnaire survey that explored their attitudes and views towards the Pharmacy profession was chosen for this study. The result showed that although at the beginning the choice to study in pharmacy was not the first one for a large number of students, as time went by, most of them felt satisfy to spend their life in studying pharmacy. Most of them knew very well about the scope of pharmacy profession. Most of Pharmay students chose the subject for their final research which related to the work field that they like to do after graduation. The 17.81 % of the pharmacy students would like to work at the pharmacy service centre (i.e hospital and community pharmacy) that directly serve the patient while others chose the other work filed. Pharmacy education should consider the currikulum which meet the work field need and that enhance the student competence.