Human dirofilariosis is a relatively rare infection caused by filarial worms of the genus Dirofilaria. We herein report the first case of human subcutaneous dirofilariosis in the southeastern part of Serbia. A complete alive nematode was removed from a nodule in the periorbital region of a 50-year-old woman. The nematode was morphologically identified as a D. repens-like immature female. The diagnosis was confirmed with molecular methods. The patient was probably infected in the South-East Serbia as she had not travelled abroad, nor in other parts of Serbia such as Vojvodina, recently identified as a hyperendemic area for D. repens infection of dogs.

So, presence of more numerous psammoma bodies' might be associated with more severe choroids plexus epithelial cells atrophy. Immunohistochemical analysis showed psammoma bodies' positive reaction on S100 protein and the presence of S100 A8/A9 positive cells in stroma of cases with psammoma bodies' positive reaction on this marker.

No abstract