To determine the prevalence of systemic diseases in patients looking for dental management in Medenta Oral and Dental Care.: The archived files of 2040 patients looking for dental management in Medenta Oral and Dental Care from 2018-2021 were retrieved and reviewed for systemic diseases. Out of 2040 patients, 1348 patients (67%) had systemic diseases. The most prevalent systemic diseases in descending order were gastro-intestinal disease (14.7%), anemia (14.3%), headaches (11.4%), depression (11.3%), and high blood pressure (5.6%). As the results indicate the prevalence of systemic diseases in dental patients is considerable, especially in women, so the dentists should pay attention while taking patients’ medical history as there could be some diseases or medications that are contraindicated for certain dental procedures or the patient may need special consideration during the treatment process. Hence, detailed and systematic history taking and accurate clinical examinations are required before starting any dental procedure.