• Metastatic breast cancer (BC) to the vitreous is very rare, with only five prior cases confirmed by vitreous biopsy having been reported in the literature. • Metastatic BC to the vitreous can present with clinical and imaging findings mimicking an infectious or inflammatory process. Novel Insights • This report is the first to document heterogenous clumpy material on the retinal surface using spectraldomain optical coherence tomography. • This report is the first to document vasculitis-like findings with modern wide-field retinal photography and fluorescein angiography.