Visual Abstract

Basal cardiac pacemaker function is regulated by concurrent PDE3+PDE4 activation which operates in a synergistic manner via decrease in cAMP/PKA phosphorylation, suppression of LCR parameters, and prolongation of the LCR period and spontaneous SANC cycle length.

and received payment for continuing medical education work related to psoriasis that was supported indirectly by Lilly and Ortho Dermatologics. 3.Dr. Tawakol reports grants from Genentech and Actelion for research outside the submitted work. 4.Dr. Powell-Wiley has received funding from the National Institutes of Health Intramural Research Program (ZIA HL006168).