Background: Colorectal cancer is the third most common cancer in the world and the fourth leading cause of cancer death. The etiology of colorectal carcinoma is an unhealthy lifestyle and a poor diet such as excessive consumption of fat. This study aims to determine the characteristic of the clinicoopatological on colorectal carcinoma patients at Sanglah Hospital Denpasar 2013-2017. Methods: A cross-sectional study was conducted with a purposive sampling technique, on all patients who met the inclusion criteria. The tools used in data collection are medical records and their complaints that are found in the Anatomy Department of Sanglah Hospital. Data recorded includes age, grade, stage, and histopathology. The data analysis method uses SPSS version 17 for Windows. Results: A total of 121 cases were collected where most were in the age range of 50-60 years, as many as 48 cases (39.7%). In addition, Grade 2 was 98 cases (81.0%), followed by histopathological type with adenocarcinoma not otherwise specified as many as 118 cases (97.5%). Stadium 2 cases were 65 cases (53.7%), and 72 cases (59.5%) were males. Conclusion: Most cases are in the range of 50-60 years of age which is followed by Grade 2, histopathological type of adenocarcinoma not otherwise specified, stage 2 and male sex

Retinoblastoma is a primary intraocular tumor on childhood. It has a good prognosis with early detection. Aim of this study is to know Pathological Risk Factors (PRF) profile of enucleated retinoblastoma at Sanglah General Hospital. This study is an observational retrospective study based on patient’s medical record and pathological examination. Twenty patients were included in this study, 50% were female and 50% male within age ranging from 7 month – 12 years old. Unilateral retinoblastoma was found in 18 patients (90.5%), bilateral retinoblastoma was found in 2 patients (9.5%). Majority PRF profile found that cancer cell invasions was 60% choroid infiltration and 45% of anterior segment invasion, 60% of optic nerve infiltration, and 50.1% scleral invasion. Tumor cell aggregation showed 61.9% poorly differentiated malignant cells. None of the patients had family history of retinoblastoma. This study revealed optic nerve and choroid invasion were the major PRF found in retinoblastoma, but there is a significant association between scleral infiltration and tumor cell differentiation (p = 0.025). There was no statistical difference of PRF based on age, gender, and laterality.

Background: Conjunctival goblet cells could be impaired and resulted in unstable tear film after small incision cataract surgery (SICS). The purpose of this study was to describe the effects of topical vitamin A on the conjunctival goblet cell density after SICS. Methods: This is a randomized clinical trial with pre-and postcontrol group design conducted in Bali Mandara Hospital on September 2015 until January 2016. A total of 38 patients were divided into two groups; 19 patients were given topical vitamin A and 19 patients were given placebo. Impression cytology specimen was obtained before SICS, after SICS and 4 weeks after intervention. Impression cytology was examined in Pathological Anatomy Laboratory of Sanglah General Hospital. Mean density of goblet cells before and after SICS were calculated using paired t-test. The difference of before and after intervention in each group were calculated using independent t-test. Results: Mean density of conjunctival goblet cells before SICS was 15.5 ± 13.4 cells/10 HPF and after SICS was 15.7 ± 12.7 cells/10 HPF (p = 0.938). Mean difference in conjunctival goblet cells density before and after SICS in the intervention group was 0.2 ± 11.7 cells/10 HPF and in the control group was -10.2 ± 8.1 cells/10 HPF (p = 0.003). The mean difference between the two groups was 10.4 ± 3.2 cells/10 HPF. Conclusions:The mean difference of conjunctival goblet cells density between two groups after intervention was found to be statistically significant. Keywords: SICS, impression cytology, topical vitamin A.Cite This Article: Handayani, A., Widhiastuti, E., Susila, N., Ekawati, N., Widiana, I., Kusumadjaja, M., Triningrat, A. 2016. Effects of topical vitamin A on conjunctival goblet cell density after small incision cataract surgery.

Background: Skin cancer is a disease caused by changes in the properties of the constituent skin cells from normal to malignant. There are 3 most common types of skin cancer: Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), and malignant melanoma. This study aims to determine the clinicopathological characteristics of non-melanoma skin cancer patients, especially BCC and SCC, at Sanglah General Hospital, Denpasar, in 2014 -2018. Methods: This study is a retrospective descriptive study. Clinicopathological data of non-melanoma skin cancer patients were obtained from the histopathological examination archive at the Anatomical Pathology Laboratory of Sanglah General Hospital from 2014 -Latar Belakang: Kanker kulit adalah salah satu penyakit yang diakibatkan oleh berubahnya sifatsifat penyusun sel kulit yang awalnya normal menjadi ganas. Terdapat 3 jenis kanker kulit yang tersering, yaitu Karsinoma Sel Basal (KSB), Karsinoma Sel Skuamosa (KSS), dan melanoma maligna. Tujuan penelitian ini adalah untuk mengetahui karakteristik klinikopatologi pasien kanker kulit non-melanoma khususnya karsinoma sel basal dan karsinoma sel skuamosa di RSUP Sanglah Denpasar pada periode tahun 2014 -2018. Metode: Penelitian ini adalah penelitian deskriptif retrospektif. Data klinikopatologi pasien kanker kulit non-melanoma diperoleh dari arsip pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSUP 2018. Data were analyzed using SPSS version 20 for Windows. Results: During 2014 -2018, there were 100 patients with non-melanoma skin cancer at Sanglah Hospital. Based on histopathological type, there were 39 cases (39.0%) of BCC and 61 cases (61.0%) of SCC. BCC was predominant in the age group above 70 years (33.33%) and the highest type of SCC in the age group 50-59 years (32.79%). Based on gender, BCC is more frequent in women by 53.85% and SCC is more frequent in men by 54.10%. Conclusion:The highest non-melanoma skin cancer cases were SCC with age more than 50 years and were more commonly found in men.Sanglah Denpasar tahun 2014 -2018. Data dianalisis dengan SPSS versi 20 untuk Windows. Hasil: Selama periode tahun 2014 -2018 terdapat 100 pasien kanker kulit non-melanoma. Berdasarkan tipe histopatologi, terdapat 39 kasus (39,00%) KSB dan 61 kasus (61,00%) KSS. KSB ditemukan terbanyak pada kelompok usia diatas 70 tahun (33,33%) dan tipe KSS terbanyak pada kelompok usia 50-59 tahun (32,79%). Berdasarkan jenis kelamin, KSB lebih banyak pada perempuan sebesar 53,85% dan KSS lebih banyak pada laki -laki sebesar 54,10%. Kesimpulan: Kasus kanker kulit non-melanoma tertinggi adalah KSS dengan usia lebih dari 50 tahun dan lebih banyak ditemukan pada laki -laki.