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Some reports of spontaneous remission and regression of cancer are preceded by a severe infection accompanied with a high fever. This paper proposes the mechanism of action of febrile infection in inducing spontaneous remission and regression of cancer and its possible implication in treating cancer patients.

Two common factors were identified among the case reports of the prolonged spontaneous remission and regression of cancer. The prolonged spontaneous remissions of cancer may be preceded by a low blood oxygen delivery to the tumor and a short, steady or rapid malignant growth. The steady or rapid growth of primary tumor not the growth of new metastases. HypotHeses Check for updatesSpontaneous remission of renal cell carcinoma may occur more commonly after nephrectomy in patients with pulmonary metastases. Spontaneous remissions of leukemia may occur more commonly after pneumonia. Spontaneous remission of Merkel cell carcinoma may occur more commonly after biopsy, etc. It is interesting that these specific events are not specific to a type of cancer, they may occur in different types of cancer. Yet, they have a higher propensity in certain types of cancer. A common denominator was sought.The etiology of the spontaneous regression or remission of cancer is unknown. Theories regarding the pathophysiology of the spontaneous regression or remission of cancer vary. It might be attributed to an immune activation, withdrawal of a possible causative agent, hormonal change, change in blood supply, cell apoptosis, tumor necrosis, infection, cytokines, chemokines, herbal remedies, etc. this study suggest that a steady or rapid growth of primary tumor faced with a low blood oxygen may result in a spontaneous regression or remission of cancer. MethodsDifferent disciplines related to cancer were studied such as biology, immunology, endocrinology, neurology, etc. as it relates to cancer. Later focus was made on the reported cases of the spontaneous regression or remission of cancer. Case Reports of the spontaneous remission and regression of cancer since the late 1800's was studied. They were classified as short and temporary or prolonged remissions. Afterwards the case reports of prolonged spontaneous remissions or regressions of cancer were classified by tissue type and events preceding the spontaneous regression or remission of cancer. The events most commonly preceding each

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