TRPC6-dependent Ca2+ flux in endothelial cells after TLR4-induced diacylglycerol production mediates lung endothelial barrier disruption and inflammation induced by LPS.

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Background: Furanocoumarin imperatorin is a major active component of Angelica dahurica root extracts exhibiting analgesic properties. Results: Imperatorin inhibited formalin-and capsaicin-induced nocifensive responses, facilitated TRPV1 desensitization, and sensitized TRPV1 to acid activation. Conclusion: Furanocoumarins represent a novel class of TRPV1 partial agonists exhibiting analgesic potential. Significance: Imperatorin is a lead compound for drug discovery aimed at developing new analgesics.

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