Surface water bodies worldwide may be contaminated with various organic contaminants. In many cases, the actual toxicity thresholds to nontarget organisms are unknown, thus presenting unknown risks. This study evaluated the potential use of floating treatment wetlands (FTWs) planted with Canna flaccida (common name: Canna) for removing two pharmaceuticals (acetaminophen and carbamazepine) and one herbicide (atrazine) from contaminated water. Triplicate FTWs with varying plant densities were established in 378 L mesocosms. After dosing the mesocosms with the contaminants, water samples were collected over a 12-week period for analysis. The planted FTWs showed differing abilities for removing acetaminophen, atrazine, and carbamazepine. Plant densities on the FTWs did not affect dissipation of acetaminophen or atrazine, but did carbamazepine. All acetaminophen residues were removed from the water within 2 weeks, while all atrazine residues were removed within 12 weeks. Approximately, 79À92% of these residues removed were associated with the FTWs. In contrast, all of the carbamazepine was not removed after 12 weeks, at which time only 29-36.7% of the total removed was associated with the FTWs. Overall results suggest that FTWs established with C. flaccida are promising for removing trace concentrations of acetaminophen, atrazine, and carbamazepine from surface water.