No abstract

This work aimed to propose a clinical sequence platform for simultaneous morphologic and quantitative imaging of joints and identified TSE-based MIXTURE (Multi-Interleaved X-prepared Turbo-Spin Echo with Intuitive Relaxometry) sequences in terms of PDFS-T2 and T1-T1ρFS combinations for clinical implementation. Even though capable of isotropic resolution, MIXTURE sequences were acquired as pseudo-3D (thicker slices, higher in-plane resolution) to match standard-clinical 2D TSE sequences. After identification of clinical demands, MIXTURE sequences were systematically optimized, while maintaining clinically feasible acquisition times of 5:00 min (PDFS-T2 for T2-mapping) and 6:40 min (T1-T1ρFS for T1ρ-mapping), and evaluated in a cadaveric human knee cartilage defect model.